Role of Genetic Testing (BRCA1 & BRCA2) in Breast Cancer Risk
Genetic testing has become one of the most powerful tools for identifying the risk of breast cancer early. Among all genetic markers, BRCA1 and BRCA2 play the biggest role in determining hereditary breast and ovarian cancer risk. Many women who consult a breast cancer specialist in Pune are advised to undergo BRCA testing if they have a strong family history of breast, ovarian, or related cancers.
What Are BRCA1 and BRCA2 Genes?
BRCA1 and BRCA2 are natural human genes responsible for repairing damaged DNA. When they work normally, they help prevent cancer formation. However, if these genes develop a mutation, they stop performing correctly, increasing the risk of cancers, especially:
Breast cancer
Ovarian cancer
Pancreatic cancer
Some lung cancers
Women with BRCA mutations have a significantly higher lifetime risk of breast cancer, which is why early evaluation through a cancer specialist in Pune is important.
Who Should Consider BRCA Genetic Testing?
You may be advised for BRCA testing if you have:
Multiple relatives with breast or ovarian cancer
A family member diagnosed at a young age
Male breast cancer in the family
A known BRCA mutation in the family
Cancer diagnosed in both breasts
Specialists such as the best medical oncologist in Pune ensure proper evaluation before recommending the test.
How Does BRCA Testing Help?
1. Early Detection and Monitoring
Individuals with BRCA mutations can start:
Regular breast MRI
Mammography screenings
Preventive check-ups
This improves the chances of detecting breast cancer early and starting breast cancer treatment in Pune without delay.
2. Helps in Preventive Measures
Depending on risk, doctors may suggest:
Medication to reduce risk
Preventive mastectomy
Removal of ovaries (for high-risk ovarian cancer)
Many patients receiving Ovarian Cancer Treatment in Pune have also benefited from early genetic screening.
3. Personalized Treatment Decisions
BRCA status helps doctors select:
Targeted therapies
PARP inhibitors
Chemotherapy plans
This is especially important in advanced breast or ovarian cancers.
Psychological and Family Benefits
Positive BRCA results help:
Family members get tested
Understand inherited cancer risks
Take preventive steps ahead of time
Hospitals such as some of the best cancer hospital in Pune now offer genetic counseling before and after testing for emotional support.
BRCA Genes and Other Cancers
Though mainly associated with breast cancer, BRCA mutations also influence risks in:
Ovarian cancer
Prostate cancer
Lung cancer
Pancreatic cancer
This is why many people consulting prostate or colorectal specialists—and even the best lung cancer specialist in Pune—are also recommended for genetic testing.
Final Takeaway
BRCA1 and BRCA2 genetic testing:
Helps detect breast cancer risk early
Allows preventive treatment planning
Enables personalized cancer therapy
Protects your family by identifying shared risk
If you have a family history of breast or ovarian cancer, consulting a breast cancer specialist in Pune can help determine whether BRCA testing is right for you.
